We have seen this painting a million times...BUT if you look closely can you actually tell without true medical diagnosis that Mona Lisa may have had a disease? One expert is speculating you CAN! The disease in question? Hypothyroidism (or under active thyroid issues). So what are the signs? Thinning hairline, no eyebrows, puffy neck, a lesion near her left eye and puffy hands! Wow....watch.